Electric Literature of C3H9NO2In 2019 ,《Novel fatty acid-based pH-responsive nanostructured lipid carriers for enhancing antibacterial delivery》 was published in Journal of Drug Delivery Science and Technology. The article was written by Osman, Nawras; Omolo, Calvin A.; Gannimani, Ramesh; Waddad, Ayman Y.; Rambharose, Sanjeev; Mocktar, Chunderika; Singh, Sanil; Parboosing, Raveen; Govender, Thirumala. The article contains the following contents:
The present study is aimed at the employment of novel fatty acid derived lipids for the preparation of pH-responsive nanostructured lipid carriers (NLCs) for vancomycin (VCM) i.v. delivery against resistant and sensitive Staphylococcus aureus bacteria. Two branched lipids [stearic acid derived solid lipid and oleic acid derived liquid lipid] were synthesized, characterized and used to fabricate NLCs by hot homogenization technique. Particle size, polydispersity index, zeta potential and encapsulation efficiency were 225.2 ± 9.1 nm, 0.258 ± 0.02, -9.2 ± 2.7 mV and 88.7 ± 13.12%, resp. An understanding of drug encapsulation efficiencies and formation of the NLCs were supported by in silico studies. In vitro antibacterial activity revealed that VCM loaded-NLCs had higher activity against methicillin-susceptible and resistant Staphylococcus aureus than the bare VCM. Cell viability study showed that NLCs had 2.5-fold better killing percentage than the bare drug at similar concentrations Furthermore, the in vivo efficacy of VCM loaded-NLCs was assessed in a mouse model of MRSA skin infection. MRSA CFU load of the skin treated with NLCs was 37-fold lower than bare VCM (p < 0.05). This novel pH-responsive NLCs may, therefore, show potential for efficient and enhanced antibiotic delivery. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H9NO2
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