In 2022,Ongaro, Alberto; Violatto, Martina Bruna; Casarin, Elisabetta; Pellerani, Isabella; Marchini, Gloria; Ribaudo, Giovanni; Salmona, Mario; Carbone, Marco; Passoni, Alice; Gnodi, Elisa; Schiavon, Elisa; Mattarei, Andrea; Barisani, Donatella; Invernizzi, Pietro; Bigini, Paolo; Morpurgo, Margherita published an article in Nanomedicine (New York, NY, United States). The title of the article was 《The mode of dexamethasone decoration influences avidin-nucleic-acid-nano-assembly organ biodistribution and in vivo drug persistence》.Category: alcohols-buliding-blocks The author mentioned the following in the article:
Avidin-Nucleic-Acid-NanoASsemblies (ANANAS) possess natural tropism for the liver and, when loaded with dexamethasone, reduce clin. progression in an autoimmune hepatitis murine model. Here, we investigated the linker chem. (hydrazide-hydrazone, Hz-Hz, or carbamate hydrazide-hydrazone, Cb-Hz bond) and length (long, 5 kDa PEG, or short, 5-6 carbons) in biotin-dexamethasone conjugates used for nanoparticle decoration through in vitro and in vivo studies. All four newly synthesized conjugates released the drug at acidic pH only. In vitro, the Hz-Hz and the PEG derivatives were less stable than the Cb-Hz and the short chain ones, resp. Once injected in healthy mice, dexamethasone location in the PEGylated ANANAS outer layer favors liver penetration and resident macrophages uptake, while drug Hz-Hz, but not Cb-Hz, short spacing prolongs drug availability. In conclusion, the tight modulation of ANANAS decoration can significantly influence the host interaction, paving the way for the development of steroid nanoformulations suitable for different pharmacokinetic profiles. In the experiment, the researchers used many compounds, for example, 6-Aminohexan-1-ol(cas: 4048-33-3Category: alcohols-buliding-blocks)
6-Aminohexan-1-ol(cas: 4048-33-3) may be used along with glutaric acid to generate poly(ester amide)s with excellent film- and fiber forming properties. It can undergo cyclization over copper supported on γ-alumina and magnesia to form hexahydro-1H-azepine.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts