Category: alcohols-buliding-blocksIn 2021 ,《Strategic Synthesis of ‘Picket Fence’ Porphyrins Based on Nonplanar Macrocycles》 appeared in European Journal of Organic Chemistry. The author of the article were Norvaisa, Karolis; Yeow, Kathryn; Twamley, Brendan; Roucan, Marie; Senge, Mathias O.. The article conveys some information:
Traditional ‘picket fence’ porphyrin systems have been a topic of interest for their capacity to direct steric shielding effects selectively to one side of the macrocycle. Sterically overcrowded porphyrin systems that adopt macrocycle deformations have recently drawn attention for their applications in organo-catalysis and sensing. Here, the authors explore the combined benefits of nonplanar porphyrins and the old mol. design to bring new concepts to the playing field. The challenging ortho-positions of meso-Ph residues in dodeca-substituted porphyrin systems led to the transition to less hindered para- and meta-sites and the development of selective demethylation based on the steric interplay. Isolation of the sym. target compound [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(3,5-dipivaloyloxyphenyl)porphyrin] was investigated under two synthetic pathways. The obtained insight was used to isolate unsym. [2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetrakis(2-nitro-5-pivaloyloxyphenyl)porphyrin]. Upon separation of the atropisomers, a detailed single-crystal X-ray crystallog. anal. highlighted intrinsic intermol. interactions. The nonplanarity of these systems in combination with ‘picket fence’ motifs provides an important feature in the design of supramol. ensembles. In addition to this study using 3,5-Dihydroxybenzaldehyde, there are many other studies that have used 3,5-Dihydroxybenzaldehyde(cas: 26153-38-8Category: alcohols-buliding-blocks) was used in this study.
3,5-Dihydroxybenzaldehyde(cas: 26153-38-8) is a building block. It has been used in the synthesis of 2,4-dimethylbenzoylhydrazones with antileishmanial and antioxidant activities.Category: alcohols-buliding-blocks
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts