Maneikyte, Juste; Bausys, Augustinas; Leber, Bettina; Feldbacher, Nicole; Hoefler, Gerald; Kolb-Lenz, Dagmar; Strupas, Kestutis; Stiegler, Philipp; Schemmer, Peter published the artcile< Dietary glycine prevents FOLFOXchemotherapy-induced heart injury: a colorectal cancer liver metastasis treatment model in rats>, Computed Properties of 1492-18-8, the main research area is colorectal cancer heart injury glycine collagen type I Hb; FOLFOX; cardiotoxicity; colorectal cancer; glycine.
This study tested the hypothesis of glycine being cardioprotective in a rat model of FOLFOX in combination with CRLM. Materials and Methods: The effect of glycine was tested in vitro on human cardiac myocytes (HCMs). To test glycine in vivo Wag/Rij rats with induced CRLM were treated with FOLFOX ±5% dietary glycine. Left ventricle ejection fraction (LVEF), myocardial fibrosis, and apoptosis, also heart fatty acid binding protein (h-FABP) and brain natriuretic peptide levels were monitored. PCR anal. for Collagen type I, II, and brain natriuretic peptide (BNP) in the heart muscle was performed. Results: In vitro glycine had no effect on HCM cell viability. Treatment with FOLFOX resulted in a significant increase of h-FABP levels, increased myocardial fibrosis, and apoptosis as well as increased expression of type I Collagen. Furthermore, FOLFOX caused a decrease of LVEF by 10% (p = 0.028). Dietary glycine prevented FOLFOX-induced myocardial injury by preserving the LVEF and reducing the levels of fibrosis (p = 0.012) and apoptosis (p = 0.015) in vivo. Conclusions: Data presented here demonstrate for the first time that dietary glycine protects the heart against FOLFOX-induced injury during treatment for CRLM.
Nutrients published new progress about Apoptosis. 1492-18-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C20H21CaN7O7, Computed Properties of 1492-18-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts