Liu, Xue-Kun’s team published research in Journal of the Chemical Society of Pakistan in 2020 | CAS: 7748-36-9

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

《Design and synthesis of 7-azaindole derivatives and their antitumor and analgesic activities》 was published in Journal of the Chemical Society of Pakistan in 2020. These research results belong to Liu, Xue-Kun; Wang, Yan-Qiu; Zhao, Tong-Jian; Lu, Yuan-Hua; Zhao, Jia-Nan; Geng, Xiao-Yu; Ma, Jie. Computed Properties of C3H6O2 The article mentions the following:

To develop effective anti-tumor and analgesic drugs, a series of novel 7-azaindole derivatives I (R = COMe, COEt, SO2Me, etc.), II were designed and synthesized through a four-step reaction. Eighteen target compounds were obtained and characterized through NMR and High Resolution Mass Spectrometry. Their anti-proliferative activities and analgesic effect were evaluated. When the 1-position was a methylsulfonyl group and the 5-position was a nitro group, compound II (R = SO2Me) demonstrated the best activity and furthermore, there was a dramatic difference between the IC50 values of this compound in tumor and in healthy cell line. The IC50 values of the above compound in MCF7 breast cancer cell line was 5.781μmol/L and 8.077μmol/L in HepG2 hepatoma carcinoma cell line, but more than 100μmol/L in HL7702 liver cell line. Preliminary results showed that compounds I (R = COMe, 3,5-(F)2SO2C6H3), II (R = SO2Ph) had significant analgesic effects in mice, which were stronger than aspirin. These compounds have good prospects for new drug development. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

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