Ling, Huiping; Li, Hong; Chen, Meijun; Lai, Baolong; Zhou, Haiming; Gao, Hui; Zhang, Jiangye; Huang, Yan; Tao, Yiwen published an article in 2021. The article was titled 《Discovery of a Highly Potent and Novel Gambogic Acid Derivative as an Anticancer Drug Candidate》, and you may find the article in Anti-Cancer Agents in Medicinal Chemistry.SDS of cas: 627-18-9 The information in the text is summarized as follows:
Gambogic Acid (GA), a promising anti-cancer agent isolated from the resin of Garcinia species in Southeast Asia, exhibits high potency in inhibiting a wide variety of cancer cells growth. Moreover, the fact that it is amenable to chem. modification makes GA an attractive mol. for the development of anti-cancer agents. Gambogic acid-3-(4-pyrimidinyloxy) Pr ester (compound 4) was derived from the reaction between 4-hydroxypropoxy pyrimidine and GA. Its structure was elucidated by comprehensive anal. of ESIMS, HRESIMS, 1 D NMR data. Anti-tumor activities of compound 4 and GA in vitro against HepG-2, A549 and MCF-7 cells were investigated by MTT assay. FITC/PI dye was used to test apoptosis. The binding affinity difference of compound 4 and GA binding to IKKΒ was studied by using Discovery Studio 2016. Compound 4 was successfully synthesized and showed strong inhibitory effects on HepG-2, A549 and MCF-7 cells lines with an IC<> 50 value of 1.49±0.11, 1.37±0.06 and 0.64±0.16μM, resp. Mol. docking study demonstrated that four more hydrogen bonds were established between IKKΒ and compound 4, compared with GA. Our results suggested that compound 4 showed significant effects in inducing apoptosis. Further mol. docking study indicated that the introduction of pyrimidine could improve GAs binding affinity to IKKbeta. Compound 4 may serve as a potential lead compound for the development of new anti-cancer drugs. In the experiment, the researchers used 3-Bromopropan-1-ol(cas: 627-18-9SDS of cas: 627-18-9)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.SDS of cas: 627-18-9
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