《Design, Synthesis, Acaricidal Activity, and Mechanism of Oxazoline Derivatives Containing an Oxime Ether Moiety》 was written by Li, Yongqiang; Li, Chaojie; Zheng, Yanlong; Wei, Xingcun; Ma, Qiaoqiao; Wei, Peng; Liu, Yuxiu; Qin, Yaoguo; Yang, Na; Sun, Yufeng; Ling, Yun; Yang, Xinling; Wang, Qingmin. Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol And the article was included in Journal of Agricultural and Food Chemistry on April 9 ,2014. The article conveys some information:
Two series of novel 2,4-diphenyl-1,3-oxazolines containing an oxime ether moiety were designed and synthesized via the key intermediate N-(2-chloro-1-(p-tolyl)ethyl)-2,6-difluorobenzamide. The bioassay results showed that the target compounds with an oxime ether substituent at the para position of 4-Ph exhibited excellent acaricidal activity against Tetranychus cinnabarinus in the laboratory Moreover, all of the target compounds had much higher activities than etoxazole, as the ovicidal and larvicidal activities of the target compounds I-a-I-l and II-a-II-n against T. cinnabarinus were all over 90% at 0.001 mg L-1, but etoxazole gave only 30% and 40% resp. at the same concentration The activity order of compounds with regard to acaricidal activity in vivo was almost consistent with their affinity activity with sulfonylurea receptor (SUR) of Blattella germanica in vitro, hence, it was supposed that the acaricidal mechanism of action of the target compounds was that they can bind with the site of SUR and therefore inhibit chitin synthesis. Moreover, the eminent effect of the compound II-l, [2-(trifluoromethyl)benzaldehyde O-(4-(2-(2,6-difluorophenyl)-4,5-dihydrooxazol-4-yl)benzyl) oxime], against Panonychus citri and T. cinnabarinus in the field indicated that II-l exhibited a promising application prospect as a new candicate for controlling spider mites in the field. In the experiment, the researchers used 2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol)
2-Amino-2-(4-methylphenyl)ethan-1-ol(cas: 157142-48-8) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 2-Amino-2-(4-methylphenyl)ethan-1-ol
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