《Titanium Salen Complexes with Appended Silver NHC Groups as Nucleophilic Carbene Reservoir for Cooperative Asymmetric Lewis Acid/NHC Catalysis》 was written by Latendorf, Katja; Mechler, Melanie; Schamne, Irina; Mack, Daniel; Frey, Wolfgang; Peters, Rene. COA of Formula: C9H11NOThis research focused ontitanium salen complex silver NHC preparation asym dimerization catalyst. The article conveys some information:
Lewis acid catalysis and nucleophilic carbene catalysis are complementary fundamental concepts to accelerate and control chem. reactions of aldehyde substrates. Their efficient merger has recently been achieved using two sep. catalyst species. The present report describes our efforts to develop a cooperative catalyst system which incorporates both features – Lewis acid and nucleophilic NHC – within the same catalyst entity. To generate free carbene moieties under very mild conditions, Ag-NHC complexes were formed releasing the nucleophilic carbene upon treatment with PPh3. The result is the formation of an enol-δ-lactone as new enal dimerization product. Silver is essential for the reactivity mode thus suggesting that it plays a double role in the catalytic event. In addition to this study using (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol, there are many other studies that have used (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7COA of Formula: C9H11NO) was used in this study.
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.COA of Formula: C9H11NO
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