《An improved protocol for the synthesis of 3,4-disubstituted isoxazol-5(4H)-ones through L-valine-mediated domino three-component strategy》 was written by Kour, Parteek; Ahuja, Monika; Sharma, Pratibha; Kumar, Ashok; Kumar, Anil. Application In Synthesis of 3-Hydroxybenzaldehyde And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2020. The article conveys some information:
An expeditious, metal-free protocol was demonstrated for the synthesis of 3,4-disubstituted isoxazol-5(4H)-one derivatives I [R = Ph, 4-ClC6H4, 4-MeOC6H4, etc.] via L-valine promoted domino three-component cyclocondensation reaction of alkyl acetoacetates, hydroxylamine hydrochloride and benzaldehydes in ethanol under reflux conditions. The reaction proceeded to deliver the desired products I in good to excellent yields (74-97%), exhibited good functional group tolerance and completed in less than 4 min with most of the substrates. Environmentally benign, high yields, short reaction time, non corrosive organocatalyst, mild reaction conditions, clean reaction profiles and the absence of any tedious workup or purification were the beneficial features of this process. Moreover, quantum computational study was performed at B3LYP/6-311G++(d, p) level to investigate the various DFT based mol. descriptors, HOMO-LUMO energy gap and electrostatic potential surface properties of compound I [R = Ph]. In the experimental materials used by the author, we found 3-Hydroxybenzaldehyde(cas: 100-83-4Application In Synthesis of 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) is used as an ionophore, during the development of an highly selective and sensitive PVC membrane sensor, which can be used as a Tb3+ ion selective electrode.Application In Synthesis of 3-Hydroxybenzaldehyde
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