Khan, Farooq-Ahmad; Nasim, Nourina; Wang, Yan; Alhazmi, Alaa; Sanam, Mehar; Ul-Haq, Zaheer; Yalamati, Damayanthi; Ulanova, Marina; Jiang, Zi-Hua published their research in European Journal of Medicinal Chemistry in 2021. The article was titled 《Amphiphilic desmuramyl peptides for the rational design of new vaccine adjuvants: Synthesis, in vitro modulation of inflammatory response and molecular docking studies》.COA of Formula: C3H7BrO The article contains the following contents:
Nucleotide-binding oligomerization domain 2 (NOD2) is cytosolic surveillance receptor of the innate immune system capable of recognizing the bacterial and viral infections. Muramyl dipeptide (MDP) is the minimal immunoreactive unit of murein. NOD2 perceives MDP as pathogen-associated mol. pattern, thereby triggering an immune response with undesirable side-effects. Beneficial properties of MDP, such as pro-inflammatory characteristics for the rational design of new vaccine adjuvants, can be harnessed by strategically re-designing the mol. In this work, a new class of amphiphilic desmuramylpeptides (DMPs) were synthesized by replacing the carbohydrate moiety (muramic acid) of the parent mol. with hydrophilic arenes. A lipophilic chain was also introduced at the C-terminus of dipeptide moiety (alanine-isoglutamine), while conserving its L-D configuration. These novel DMPs were found to set off the release of higher levels of tumor necrosis factor alpha (TNF-α) than Murabutide, which is a well-known NOD2 agonist. Mol. docking studies indicate that all these DMPs bind well to NOD2 receptor with similar dock scores (binding energy) through a number of hydrogen bonding and hydrophobic/π interactions with several crucial residues of the receptor. More studies are needed to further assess their immunomodulatory therapeutic potential, as well as the possible involvement of NOD2 activation. In the experimental materials used by the author, we found 3-Bromopropan-1-ol(cas: 627-18-9COA of Formula: C3H7BrO)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.COA of Formula: C3H7BrO
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