In 2015,Karlsson, Staffan; Bergman, Rolf; Loefberg, Christian; Moore, Peter R.; Ponten, Fritiof; Tholander, Joakim; Soerensen, Henrik published 《Development of a Large-Scale Route to an MCH1 Receptor Antagonist: Investigation of a Staudinger Ketene-Imine Cycloaddition in Batch and Flow Mode》.Organic Process Research & Development published the findings.SDS of cas: 18621-18-6 The information in the text is summarized as follows:
A practical large-scale route to an MCH1 receptor antagonist, azetidinyl oxadiazole I, is described. A Staudinger β-lactam synthesis of an imine and an in situ generated ketene was utilized as a key step for the preparation of a spiro-azetidine building block. The reaction was demonstrated in both batch and flow mode and a comparison of these techniques is described. In the experimental materials used by the author, we found Azetidin-3-ol hydrochloride(cas: 18621-18-6SDS of cas: 18621-18-6)
Azetidin-3-ol hydrochloride(cas:18621-18-6) is one of azetidine.Azetidines (azacyclobutanes) constitute a well-known class of heterocyclic compounds. Azetidine scaffold has been discovered in several natural products.SDS of cas: 18621-18-6 Several pharmacologically important synthetic compounds also contain azetidine ring. Because of inherent ring strain, the synthesis of azetidines is a challenging endeavor.
Referemce:
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Alcohols – Chemistry LibreTexts