In 2019,Journal of the American Chemical Society included an article by Kang, Zhenghui; Wang, Yongheng; Zhang, Dan; Wu, Ruibo; Xu, Xinfang; Hu, Wenhao. Safety of (4-Bromophenyl)methanol. The article was titled 《Asymmetric Counter-Anion-Directed Aminomethylation: Synthesis of Chiral β-Amino Acids via Trapping of an Enol Intermediate》. The information in the text is summarized as follows:
In the presence of allylpalladium chloride dimer and a penta-(-)-menthyl cyclopentadienepentacarboxylate, diazo esters such as PhC(:N2)CO2Me underwent enantioselective three-component aminomethylation reactions with alcs. such as benzyl alc. and (methoxymethyl)amines such as MeOCH2NBn2 (Bn = PhCH2) to yield nonracemic α-alkoxy-β-amino esters such as I. The mechanism of the reaction was studied using in-situ generated intermediates and DFT calculations; the reaction likely occurs by stereoselective trapping of an in situ-generated enol with an iminium ion through hydrogen bonding and electrostatic interactions with a nonracemic pentacarboxycyclopentadiene anion. After reading the article, we found that the author used (4-Bromophenyl)methanol(cas: 873-75-6Safety of (4-Bromophenyl)methanol)
(4-Bromophenyl)methanol(cas: 873-75-6) undergoes three-component reaction with acetylferrocene and arylboronic acid to give ferrocenyl ketones containing biaryls.Safety of (4-Bromophenyl)methanol It is used in the synthesis of amphiphilic, symmetric rod-coil, triblock copolymer of poly(9,9-didodecylfluorene-2,7-diyl) and poly(hydroxyl ethyl methacrylate)
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts