In 2018,Iacono, Carmelo E.; Stephens, Thomas C.; Rajan, Teena S.; Pattison, Graham published 《A Coupling Approach for the Generation of α,α-Bis(enolate) Equivalents: Regioselective Synthesis of gem-Difunctionalized Ketones》.Journal of the American Chemical Society published the findings.Application of 78782-17-9 The information in the text is summarized as follows:
Regioselective α,α-difunctionalization adjacent to a ketone is a significant synthetic challenge. Here, we present a solution to this problem through the transition-metal-free coupling of esters with geminal bis(boron) compounds This forms an α,α-bis(enolate) equivalent which can be trapped with electrophiles including alkyl halides and fluorinating agents. This presents an efficient, convergent synthetic strategy for the synthesis of unsym. blocked ketones. After reading the article, we found that the author used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Application of 78782-17-9)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds. Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.Application of 78782-17-9
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