Huo, Shuaicong; Kong, Siqi; Zeng, Guang; Feng, Qi; Hao, Zhiqiang; Han, Zhangang; Lin, Jin; Lu, Guo-Liang published the artcile< Efficient access to quinolines and quinazolines by ruthenium complexes catalyzed acceptorless dehydrogenative coupling of 2-aminoarylmethanols with ketones and nitriles>, Safety of (2-Aminophenyl)methanol, the main research area is quinoline preparation; quinazoline preparation; ketone aminoarylmethanol dehydrogenative coupling reaction ruthenium catalyst; nitrile aminoarylmethanol dehydrogenative coupling reaction ruthenium catalyst.
Treatment of N,N,O-tridentate pyrazolyl-pyridinyl-alc. ligands, I (R = H, Me; R1 = H, Me, Ph; R2 = Me, Ph) with RuCl3·xH2O in refluxing EtOH afforded the corresponding Ru(III) complexes II, as chlorides, which were well characterized by IR, HR-MS and X-ray single crystal structural determination These Ru complexes II showed similarly high catalytic performance for both dehydrogenative couplings of 2-aminoarylmethanols [2-NH2-3-R3-5-R4C6H2CH2OH (R3 = H, Me, Br; R4 = H, F, Cl, Br) and 3-amino-3-phenyl-1-propanol] with ketones [R5C(O)CH3 (R5 = Ph, pyridin-3-yl, thiophen-2-yl, etc.), cycloheptanone and 1,2,3,4-tetrahydronaphthalen-1-one] and nitriles R6CN (R6 = Ph, 3-bromophenyl, thien-2-yl, etc.), giving the quinolines III, IV, V and 2,6-diphenylpyridine and quinazolines VI in good to excellent yields. This protocol provides an atom-economical and sustainable route to access various structurally important quinolines III, IV, V and 2,6-diphenylpyridine and quinazolines VI derivatives by using phosphine-free ligand based Ru catalysts II.
Molecular Catalysis published new progress about Amino alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Safety of (2-Aminophenyl)methanol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts