Recommanded Product: 27489-62-9In 2019 ,《Optimization of 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidines to generate a highly selective PI3Kδ inhibitor》 was published in Bioorganic & Medicinal Chemistry. The article was written by Hamajima, Toshihiro; Takahashi, Fumie; Kato, Koji; Sugano, Yukihito; Yamaki, Susumu; Suzuki, Daisuke; Moritomo, Ayako; Kubo, Satoshi; Nakamura, Koji; Yamagami, Kaoru; Yokoo, Koji; Fukahori, Hidehiko. The article contains the following contents:
Chem. optimization of the 5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine (THPP) scaffold was conducted with a focus on cellular potency while maintaining high selectivity against PI3K isoforms. Compound I was identified as a potent, highly selective and orally available PI3Kδ inhibitor. In addition, I exhibited efficacy in an in vivo antibody production model. The desirable drug-like properties and in vivo efficacy of I suggest its potential as a drug candidate for the treatment of autoimmune diseases and leukocyte malignancies. The experimental part of the paper was very detailed, including the reaction process of trans-4-Aminocyclohexanol(cas: 27489-62-9Recommanded Product: 27489-62-9)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 27489-62-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts