Category: alcohols-buliding-blocksOn June 1, 2018, Gupta, Sampa; Adhikary, Sulekha; Modukuri, Ram K.; Choudhary, Dharmendra; Trivedi, Ritu; Sashidhara, Koneni V. published an article in Bioorganic & Medicinal Chemistry Letters. The article was 《Benzofuran-pyran hybrids: A new class of potential bone anabolic agents》. The article mentions the following:
Benzofuran moiety is an important pharmacophore showing pos. effects on bone health. In the present study, sixteen benzofuran-pyran hybrids were synthesized and were evaluated for their osteogenic effects on primary osteoblast cells isolated from calvaria. Compounds 22 and 24 were found potent in stimulating osteoblast differentiation as assessed by the alk. phosphatase activity. These compounds were also found to be nontoxic to osteoblast cells as compared to the control cells in MTT assay. Further, Alizarin Red-S staining for visualization of calcium nodules demonstrated compounds 22 and 34 as active in enhancing mineralization in osteoblast cells. Addnl., transcriptional anal. of these compounds on osteoblast cells revealed that compound 22 up-regulated the expression of osteogenic genes RUNX2, BMP-2, COL-1, thus substantiating that compound 22 having two geminal Me groups in its R3 position is a potent osteogenic agent. Addnl., compound 22 enhanced the ability of bone marrow stromal cells to differentiate towards osteoblast lineage and therefore can be further studied in vivo in bone loss model. In the experiment, the researchers used many compounds, for example, 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Category: alcohols-buliding-blocks)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Category: alcohols-buliding-blocksDeprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts