In 2017,Gunia-Krzyzak, Agnieszka; Zelaszczyk, Dorota; Rapacz, Anna; Zeslawska, Ewa; Waszkielewicz, Anna M.; Panczyk, Katarzyna; Sloczynska, Karolina; Pekala, Elzbieta; Nitek, Wojciech; Filipek, Barbara; Marona, Henryk published 《Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3》.Bioorganic & Medicinal Chemistry published the findings.Quality Control of trans-4-Aminocyclohexanol The information in the text is summarized as follows:
A series of twenty two (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in Ph ring with 4-Cl, 4-CH3 or 2-CH3 was designed, synthesized and evaluated for anticonvulsant activity in rodent models of seizures: maximal electroshock (MES) test, s.c. pentylenetetrazole (scPTZ) test, and 6-Hz test. There were identified three most active compounds: S-(2E)-N-(1-hydroxypropan-2-yl)-3-(2-methylphenyl)prop-2-enamide (5) (ED50 MES = 42.56, ED50 scPTZ = 58.38, ED50 6-Hz 44 mA = 42.27 mg/kg tested in mice after i.p. (i.p.) administration); R,S-(2E)-3-(4-chlorophenyl)-N-(1-hydroxybutan-2-yl)prop-2-enamide (6) (ED50 MES = 53.76, ED50 scPTZ = 90.31, ED50 6-Hz 44 mA = 92.86 mg/kg mice, i.p.); and R,S-(2E)-3-(4-chlorophenyl)-N-(2-hydroxypropyl)prop-2-enamide (11) (ED50 MES = 55.58, ED50 scPTZ = 102.15, ED50 6-Hz 44 mA = 51.27 mg/kg mice, i.p.). Their structures and configurations were confirmed by crystal X-ray diffraction method. The structure-activity studies among the tested series showed that chlorine atom in position para or Me group in position ortho of Ph ring were beneficial for anticonvulsant activity. Me group in position para of Ph ring decreased anticonvulsant activity in reported series of cinnamamide derivatives The experimental process involved the reaction of trans-4-Aminocyclohexanol(cas: 27489-62-9Quality Control of trans-4-Aminocyclohexanol)
trans-4-Aminocyclohexanol(cas: 27489-62-9) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Quality Control of trans-4-Aminocyclohexanol
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