《Molecular structure of cefuroxime axetil complexes with α-, β-, γ-, and 2-hydroxypropyl-β-cyclodextrins: molecular simulations and Raman spectroscopic and imaging studies》 was published in International Journal of Molecular Sciences in 2021. These research results belong to Gieroba, Barbara; Kalisz, Grzegorz; Sroka-Bartnicka, Anna; Plazinska, Anita; Plazinski, Wojciech; Starek, Malgorzata; Dabrowska, Monika. HPLC of Formula: 54-17-1 The article mentions the following:
The formation of cefuroxime axetil + cyclodextrin (CA + CD) complexes increases the aqueous solubility of CA, improves its physico-chem. properties, and facilitates a biomembrane-mediated drug delivery process. In CD-based tablet formulations, it is crucial to investigate the mol. details of complexes in final pharmaceutical preparation In this study, Raman spectroscopy and mapping were applied for the detection and identification of chem. groups involved in α-, β-, γ-, and 2-hydroxypropyl-β-CD (2-HP- β-CD) + CA complexation process. The exptl. studies have been complemented by mol. dynamics-based investigations, providing addnl. mol. details of CA + CD interactions. It has been demonstrated that CA forms the guest-host type inclusion complexes with all studied CDs; however, the nature of the interactions is slightly different. It seems that both α- and β-CD interact with furanyl and methoxy moieties of CA, γ-CD forms a more diverse pattern of interactions with CA, which are not observed in other CDs, whereas 2HP-β-CD binds CA with the contribution of hydrogen bonding. Apart from supporting this interpretation of the exptl. data, mol. dynamics simulations allowed for ordering the CA + CD binding affinities. The obtained results proved that the mol. details of the host-guest complexation can be successfully predicted from the combination of Raman spectroscopy and mol. modeling. The results came from multiple reactions, including the reaction of rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1HPLC of Formula: 54-17-1)
rel-(3R,4S,5S,6R)-6-(Hydroxymethyl)tetrahydro-2H-pyran-2,3,4,5-tetraol(cas: 54-17-1) is oxidized in various tissues under either aerobic or anaerobic conditions through glycolysis; the oxidation reaction produces carbon dioxide, water, and ATP.HPLC of Formula: 54-17-1
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