In 2019,Angewandte Chemie, International Edition included an article by Garreau, Marion; Le Vaillant, Franck; Waser, Jerome. Reference of 3-Bromopropan-1-ol. The article was titled 《C-Terminal bioconjugation of peptides through photoredox catalyzed decarboxylative alkynylation》. The information in the text is summarized as follows:
We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. By the use of hypervalent iodine reagents, the introduction of a broad range of functional groups was successful. C-terminal selectivity was achieved by differentiation of the oxidation potentials of the carboxylic acids based on the use of fine-tuned organic dyes. The experimental process involved the reaction of 3-Bromopropan-1-ol(cas: 627-18-9Reference of 3-Bromopropan-1-ol)
3-Bromopropan-1-ol(cas: 627-18-9) was used in the synthesis of fluorescent halide-sensitive quinolinium dyes and molten salt-polymers. Furthermore, it was used in the synthesis of chiral, quaternary prolines via cyclization of quaternary amino acids.Reference of 3-Bromopropan-1-ol
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