HPLC of Formula: 126456-43-7In 2020 ,《CuII/TEMPO-Catalyzed Enantioselective C(sp3)-H Alkynylation of Tertiary Cyclic Amines through Shono-Type Oxidation》 was published in Angewandte Chemie, International Edition. The article was written by Gao, Pei-Sen; Weng, Xin-Jun; Wang, Zhen-Hua; Zheng, Chao; Sun, Bing; Chen, Zhi-Hao; You, Shu-Li; Mei, Tian-Sheng. The article contains the following contents:
A novel strategy for asym. Shono-type oxidative cross-coupling has been developed by merging copper catalysis and electrochem., affording C1-alkynylated tetrahydroisoquinolines with good to excellent enantioselectivity. The use of TEMPO as a co-catalytic redox mediator is crucial not only for oxidizing a tetrahydroisoquinoline to an iminium ion species but also for decreasing the oxidation potential of the reaction. A novel bisoxazoline ligand is also reported. The results came from multiple reactions, including the reaction of (1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7HPLC of Formula: 126456-43-7)
(1S,2R)-1-Amino-2,3-dihydro-1H-inden-2-ol(cas: 126456-43-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 126456-43-7
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