In 2022,Elberskirch, Linda; Le Harzic, Ronan; Scheglmann, Dietrich; Wieland, Gerhard; Wiehe, Arno; Mathieu-Gaedke, Maria; Golf, Hartwig R. A.; von Briesen, Hagen; Wagner, Sylvia published an article in European Journal of Pharmaceutical Sciences. The title of the article was 《A HET-CAM based vascularized intestine tumor model as a screening platform for nano-formulated photosensitizers》.Application of 534-03-2 The author mentioned the following in the article:
The development of new tumor models for anticancer drug screening is a challenge for preclin. research. Conventional cell-based in vitro models such as 2D monolayer cell cultures or 3D spheroids allow an initial assessment of the efficacy of drugs but they have a limited prediction to the in vivo effectiveness. In contrast, in vivo animal models capture the complexity of systemic distribution, accumulation, and degradation of drugs, but visualization of the individual steps is challenging and extracting quant. data is usually very difficult. Furthermore, there are a variety of ethical concerns related to animal tests. In accordance with the 3Rs principles of Replacement, Reduction and Refinement, alternative test systems should therefore be developed and applied in preclin. research. The Hen’s egg test on chorioallantoic membrane (HET-CAM) model provides the generation of vascularized tumor spheroids and therefore, is an ideal test platform which can be used as an intermediate step between in vitro anal. and preclin. evaluation in vivo. We developed a HET-CAM based intestine tumor model to investigate the accumulation and efficacy of nano-formulated photosensitizers. Irradiation is necessary to activate the phototoxic effect. Due to the good accessibility of the vascularized tumor on the CAM, we have developed a laser irradiation setup to simulate an in vivo endoscopic irradiation The study presents quant. as well as qual. data on the accumulation and efficacy of the nano-formulated photosensitizers in a vascularized intestine tumor model. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Application of 534-03-2) was used in this study.
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 534-03-2
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