Chistov, Alexey A.’s team published research in European Journal of Medicinal Chemistry in 2019 | CAS: 13325-10-5

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

The author of 《Compounds based on 5-(perylen-3-ylethynyl)uracil scaffold: High activity against tick-borne encephalitis virus and non-specific activity against enterovirus A》 were Chistov, Alexey A.; Orlov, Alexey A.; Streshnev, Philipp P.; Slesarchuk, Nikita A.; Aparin, Ilya O.; Rathi, Brijesh; Brylev, Vladimir A.; Kutyakov, Sergey V.; Mikhura, Irina V.; Ustinov, Alexey V.; Westman, Gunnar; Palyulin, Vladimir A.; Jain, Nidhi; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Korshun, Vladimir A.. And the article was published in European Journal of Medicinal Chemistry in 2019. HPLC of Formula: 13325-10-5 The author mentioned the following in the article:

Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogs of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid and its amides I (R = Bu, CH2CH(OH)CMe2CH2OH, (CH2)2OH, etc.; R1 = H, (CH2)2OH) were synthesized using combined protection group strategy and those compounds appeared to have low toxicity on porcine embryo kidney (PEK) or rhabdomiosarcoma (RD) cells together with remarkable activity against enveloped tick-borne encephalitis virus (TBEV): EC50 values vary from 0.077 μM to subnanomolar range. Surprisingly, 3-pivaloyloxymethyl (Pom) protected 5-(perylen-3-ylethynyl)uracil-1-acetic acid precursors showed even more pronounced activity. All the compounds showed no activity against several non-enveloped enteroviruses, except 4-hydroxybutylamides I (R = (CH2)4OH; R1 = H) and (R= CH2CH(OH)CMe2CH2OH; R1 = H), which inhibited the reproduction of enterovirus A71 with EC50 50-100 μM, with a non-specific mode of action. The results suggest that the carbohydrate moiety of RAFI nucleosides does not play a crucial role in their antiviral action, and biol. activity of the 5-(perylen-3-ylethynyl)uracil scaffold can be effectively modulated by substituents in positions 1 and 3. The high antiviral activity of these new compounds, coupled with low toxicity advocate their potential role in antiviral therapy. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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