Chen, Yuqing; Liu, Dan; Wang, Dingyi; Lai, Shanshan; Zhong, Ruting; Liu, Yuanyuan; Yang, Chengfeng; Liu, Bin; Sarker, Moklesur Rahman; Zhao, Chao published the artcile< Hypoglycemic activity and gut microbiota regulation of a novel polysaccharide from Grifola frondosa in type 2 diabetic mice>, Related Products of 3458-28-4, the main research area is Grifola polysaccharide type 2 diabetes gut microbiota regulation hypoglycemia; Grifola frondosa polysaccharide; Hypoglycemic; Intestinal microflora; Purification; Single-molecule real-time sequencing.
GFP-N, a novel heteropolysaccharide with a mol. weight of 1.26 × 107 Da, was isolated from maitake mushroom and purified by anion-exchange chromatog. on a DEAE cellulose-52 column and gel-filtration chromatog. on a Sephadex G-100 column. Its structure was characterized by Fourier transform IR spectroscopy and one-dimensional (1H- and 13C-) NMR spectra, 1H-1H correlation spectroscopy, and 1H-13C heteronuclear single-quantum coherence spectroscopy. The structure of GFP-N consisted of L-arabinose, D-mannose and D-glucose and mainly contained three kinds of linkage type units as( →2,6)-a-D-Manp-(1 → 4, a-L-Araf-C1→, and →3,6)-β-D-Glcp-(1 →). GFP-N could activate insulin receptor substrate 1, phosphatidylinositol-3-kinase, and glucose transporter 4 and inhibit c-Jun N-terminal kinase 1/2 for hypoglycemic effects in diabetic mouse livers. This is also the first report of the regulatory efficacy of Grifola frondosa polysaccharide on intestinal microflora in vivo using single-mol. real-time sequencing. These results indicated that polysaccharide from maitake mushroom could be as an enhancer to improve type 2 diabetes and a healthy food option to help regulate gut microbiota in diabetic individuals.
Food and Chemical Toxicology published new progress about Actinobacteria. 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Related Products of 3458-28-4.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts