《The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents》 was written by Chappel, Lucy; Wong, Lai Chun; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.. Product Details of 534-03-2This research focused ontrifluoromethylated nitroarylaminodichloropropane derivative preparation antitumor agent; Anti-cancer agents; Nitroaromatic drugs; Nitrogen mustards; Trifluoromethylated drugs. The article conveys some information:
Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives were prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Anal. of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 534-03-2
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts