Cai, Aijie; Yan, Wenhao; Wang, Chao; Liu, Wei published the artcile< Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds>, Quality Control of 167938-56-9, the main research area is alkyl iodide copper catalyst difluoromethylation; alkyldifluoromethane preparation; copper; cross-coupling; difluoromethylation; radicals; reaction mechanisms.
A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products.
Angewandte Chemie, International Edition published new progress about Aralkyl halides, iodides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 167938-56-9 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H17NO3, Quality Control of 167938-56-9.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts