In 2022,Banerjee, Arghya; Sarkar, Satavisha; Shah, Jagrut A.; Frederiks, Nicoline C.; Bazan-Bergamino, Emmanuel A.; Johnson, Christopher J.; Ngai, Ming-Yu published an article in Angewandte Chemie, International Edition. The title of the article was 《Excited-State Copper Catalysis for the Synthesis of Heterocycles》.Product Details of 7748-36-9 The author mentioned the following in the article:
Herein, the discovery and development of visible-light-induced, synergistic excited-state copper catalysis using a combination of Cu(IPr)I as a catalyst and rac-BINAP as a ligand, which produces more than 10 distinct classes of heterocycles was reported. The reaction tolerated a broad array of functional groups and complex mol. scaffolds, including derivatives of peptides, natural products and marketed drugs. Preliminary mechanistic investigation suggested in situ generations of [Cu(BINAP)2]+ and [Cu(IPr)2]+ catalysts that work cooperatively under visible-light irradiation to facilitate catalytic carbo-aroylation of unactivated alkenes, affording a wide range of useful heterocycles. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts