Arslan, Burcu; Gulcemal, Suleyman published the artcile< α-Alkylation of arylacetonitriles with primary alcohols catalyzed by backbone modified N-heterocyclic carbene iridium(I) complexes>, Computed Properties of 5344-90-1, the main research area is nitrogen heterocyclic carbene iridium complex preparation; aryl arylpropanenitrile preparation; arylquinolin amines preparation; arylacetonitrile alc alpha alkylation catalyst nitrogen heterocyclic carbene iridium.
A series of backbone-modified N-heterocyclic carbene (NHC) complexes of iridium(I) I [Ar = 4-MeOC6H4; Y = X = Ph, 4-MeOC6H4; YX = HC=CHCH=CH] had been synthesized and characterized. The electronic properties of the NHC ligands had been assessed by comparison of the IR carbonyl stretching frequencies of the in situ prepared [IrCl(CO)2(NHC)] complexes in CH2Cl2. These new complexes I [Ar = Ph, 4-CF3C6H4, 4-MeOC6H4; Y = X = H], together with previously prepared I [Ar = 4-MeOC6H4; Y = X = Ph, 4-MeOC6H4; YX = HC=CHCH=CH], were applied as catalysts for the α-alkylation of arylacetonitriles with an equimolar amount of primary alcs. or 2-aminobenzyl alc. The catalytic activities of these complexes I [Ar = Ph, 4-CF3C6H4, 4-MeOC6H4; Y = X = H, Ph, 4-MeOC6H4; YX = HC=CHCH=CH] could be controlled by modifying the N-substituents and backbone of the NHC ligands. The NHC-IrI complex I [Ar = Y = X = 4-MeOC6H4] bearing 4-methoxybenzyl substituents on the N-atoms and 4-methoxyphenyl groups at the 4,5-positions of imidazole exhibited the highest catalytic activity in the α-alkylation of arylacetonitriles with primary alcs. Various α-alkylated nitriles Ar1CH(CN)CH2Ar2 [Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, etc.; Ar2 = Ph, 2-pyridyl, 4-MeC6H4, etc.] and aminoquinolines II [R = H, Cl, Br, Me, OMe] were obtained in high yields through a borrowing hydrogen pathway by using 0.1 mol% I [Ar = Y = X = 4-MeOC6H4] and a catalytic amount of KOH (5 mol%) under an air atm. within significantly short reaction times.
Dalton Transactions published new progress about Acetonitriles Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, Computed Properties of 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts