In 2022,Ansari, Sumaira; Mushtaq, Nousheen; Ahmed, Ahsaan; Asghar, Saira; Munawar, Rabya; Saify, Zafar Saied published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Synthesis, biological screening and docking studies of some indole derivatives as potential antioxidant》.Safety of Oxetan-3-ol The author mentioned the following in the article:
The present study envisioned some antioxidant candidates having 1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indoles I [R = Ph, 4-FC6H4, 2,4,6-tri-MeC6H2, etc.; Y = C(O), C(O)CH2, SO2, C(O)CH2CH2], 3-(2-bromoethyl)indole (BEI) and 7-azindole (AI) nucleus. Derivatives of these indole mols. were synthesized and their scavenging activity for reactive oxygen species (ROS) investigated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. Compounds I [R = biphenyl-4-yl, Y = CH2C(O); R = 2,4,6-tri-MeC6H2, Y = SO2] exhibited significant radical scavenging potential which was comparable to ascorbic acid (standard), while compound I [R = 2-naphthyl, Y = CH2C(O)] appeared as most potent antioxidant by displaying better scavenging activity than standard mol. Mol. docking study revealed good binding score and interactions of compound I [R = 2-naphthyl, Y = CH2C(O)] with target human antioxidant enzyme (PDB code: 3MNG) validating the results of biol. activity. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts