Ahmadi, Reza; Ebrahimzadeh, Mohammad Ali published the artcile< Resveratrol - A comprehensive review of recent advances in anticancer drug design and development>, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol, the main research area is review resveratrol derivative cancer drug design development; Anticancer; Antitumor; Chemotherapy; Phytoalexin; Polyphenol; Resveratrol; Stilbenoid.
A review. Resveratrol is a natural polyphenolic stilbene isolated from various plants, foods and beverages with a broad spectrum of biol. and pharmacol. properties through modulating diverse targets and signaling pathways. Particularly, it has attracted a great deal of attention as a promising and multitarget anticancer agent due to its potential use in chemoprevention and chemotherapy of various tumors. However, unfavorable pharmacokinetics/pharmacodynamics profile such as poor bioavailability restricted its applications. Therefore, medicinal chemists have synthesized a lot of novel derivatives and analogs of resveratrol using different modification strategies to overcome these limitations and improve anticancer efficacy. Herein, we reviewed the design, synthesis, structure-activity relationship and mechanism of the most potent and privileged resveratrol-based compounds that showed promising anticancer activities in the last five years. We classified these compounds into the ten different categories based on their chem. structure similarities.
European Journal of Medicinal Chemistry published new progress about Antitumor agents. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Recommanded Product: (E)-5-(4-Hydroxystyryl)benzene-1,3-diol.
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