Safety of 4,4-Diethoxybutan-1-amineOn September 28, 2020 ,《Direct Reductive Amination of Camphor Using Iron Pentacarbonyl as Stoichiometric Reducing Agent: Features and Limitations》 was published in European Journal of Organic Chemistry. The article was written by Afanasyev, Oleg I.; Fatkulin, Artemy R.; Solyev, Pavel N.; Smirnov, Ivan; Amangeldyev, Artem; Semenov, Sergey E.; Chusov, Denis. The article contains the following contents:
The method of direct reductive amination of camphor and fenchone was proposed. The most effective reducing agent is iron pentacarbonyl. No ligands or solvents are needed. The stereochem. of the corresponding products was determined by HMBC, HSQC, and NOESY spectra. The limitations of the method were shown. The reaction of camphor with primary amines led to exclusively exo product, while the reaction of fenchone led to exclusively endo product. The reaction of camphor with cyclic secondary amines led to the mixture of endo and exo isomers. The experimental process involved the reaction of 4,4-Diethoxybutan-1-amine(cas: 6346-09-4Safety of 4,4-Diethoxybutan-1-amine)
4,4-Diethoxybutan-1-amine(cas: 6346-09-4) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Safety of 4,4-Diethoxybutan-1-amine
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