Zhang, Qingchun; Feng, Shufan; Zhao, Yulian; Jin, Bo; Peng, Rufang published an article in 2021. The article was titled 《Design and synthesis of N-hydroxyalkyl substituted deferiprone: a kind of iron chelating agents for Parkinson′s disease chelation therapy strategy》, and you may find the article in JBIC, Journal of Biological Inorganic Chemistry.Computed Properties of C4H11NO The information in the text is summarized as follows:
The blood-brain barrier (BBB) permeability of mols. needs to meet stringent requirements of Lipinski′s rule, which pose a difficulty for the rational design of efficient chelating agents for Parkinson′s disease chelation therapy. Therefore, the iron chelators employed N-aliphatic alcs. modification of deferiprone were reasonably designed in this work. The chelators not only meet Lipinski′s rule for BBB permeability, but also ensure the iron affinity. The results of solution thermodn. demonstrated that the pFe3+ value of N-hydroxyalkyl substituted deferiprone is between 19.20 and 19.36, which is comparable to that of clin. deferiprone. The results of 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays indicated that the N-hydroxyalkyl substituted deferiprone also possesses similar radical scavenging ability in comparison to deferiprone. Meanwhile, the Cell Counting Kit-8 assays of neuron-like rat pheochromocytoma cell-line demonstrated that the N-hydroxyalkyl substituted deferiprone exhibits extremely low cytotoxicity and excellent H2O2-induced oxidative stress protection effect. These results indicated that N-hydroxyalkyl substituted deferiprone has potential application prospects as chelating agents for Parkinson′s disease chelation therapy strategy. Graphic abstract: [graphic not available: see fulltext] The experimental part of the paper was very detailed, including the reaction process of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO
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