Zhang, Cheng; Sun, Qiaoying; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K. published the artcile< Gold-Catalyzed Regiodivergent Annulations of Diazo-Alkynes Controlled by Et3N(HF)3>, Name: But-3-en-1-ol, the main research area is ethyl aryl alkyl naphthoate regioselective preparation; phenyl ethyl diazo oxopropanoate annulation catalyst gold.
Selectivity control in catalytic carbene insertions was known to be dominated by the adjustment of both the electronic and steric properties of metal complexes. Herein, a conceptually distinct strategy that enables a regioselectivity switch for the gold-catalyzed carbohydroxylation of diazo-tethered alkynes controlled by the additive Et3N(HF)3 for synthesis of Et (aryl/alkyl)-naphthoates was I [R1 = OH, Ph, 4-MeC6H4, etc.; R2 = F, OH, Ph, etc.; R3 = H, 7-F, 7-MeO, etc.] reported. Depending on the reaction conditions, either direct carbohydroxylation was observed or Michael addition/1,2-shift of the quinoid carbene intermediate in the presence of a Bronsted acid was involved. In both cases, the reaction proceeded with high regioselectivity. An intramol. cascade fluorination process for the synthesis of aryl fluorides I [R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = F; R3 = H, 7-F, 7-MeO, etc.] in high yield, which could be triggered under inert conditions and the use of Et3N(HF)3 was described.
ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts