Wang, Ze-Shu; Chen, Yang-Bo; Wang, Kun; Xu, Zhou; Ye, Long-Wu published the artcile< One-pot synthesis of 2-hydroxymethylindoles via photoredox-catalyzed ketyl-ynamide coupling/1,3-allylic alcohol transposition>, SDS of cas: 5344-90-1, the main research area is benzoyl arylethynyl alkylsulfonamide iridium photocatalyst regioselective coupling reaction; hydroxymethylindole preparation.
An efficient visible-light-mediated ketyl-ynamide coupling by employing ynamides bearing alkyl sulfonyl substituents to deliver eneindolin-3-ols was developed. Subsequent 1,3-transposition of allylic alcs. in one pot was capable of synthesizing 2-hydroxymethylindoles in generally moderate to good yields. The synthetic utility of this protocol was also demonstrated by the facile and practical synthesis of two bioactive mols. The use of readily available substrates, a simple procedure and benign reaction conditions render this method a viable alternative for the synthesis of 2-hydroxymethylindoles.
Green Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5344-90-1 belongs to class alcohols-buliding-blocks, and the molecular formula is C7H9NO, SDS of cas: 5344-90-1.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts