In 2019,International Journal of Biological Macromolecules included an article by Valiey, Ehsan; Dekamin, Mohammad G.; Alirezvani, Zahra. Name: 3-Hydroxybenzaldehyde. The article was titled 《Melamine-modified chitosan materials: An efficient and recyclable bifunctional organocatalyst for green synthesis of densely functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives》. The information in the text is summarized as follows:
An environmentally benign protocol for diversity-oriented synthesis of functionalized bioactive dihydropyrano[2,3-c]pyrazole and benzylpyrazolyl coumarin derivatives has been investigated by the reaction of aryl aldehydes, Et acetoacetate, hydrazine derivatives, malononitrile and 4-hydroxycoumarin in the presence of melamine-modified chitosan (Cs-Pr-Me) materials as a reusable bifunctional organocatalyst. The Cs-Pr-Me materials were properly characterized by the Fourier transform IR (FTIR) spectroscopy, CHN elemental anal., thermal gravimetric (TGA) and derivative thermogravimetric (DTG) anal., field emission SEM (FESEM) and energy-dispersive X-ray (EDX) spectroscopy. The remarkable advantages of this green protocol are high to quant. yields of the desired products, short reaction times, wide scope, simple work-up procedure and low loading of a transition metal-free catalyst. An addnl. advantage of this bio-based organocatalyst is the ability to sep. and recycle it easily from the reaction mixture with minimal effort in subsequent runs without significant loss of its catalytic activity. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts