Torretta, Simone; Scagliola, Alessandra; Ricci, Luisa; Mainini, Francesco; Di Marco, Sabrina; Cuccovillo, Ivan; Kajaste-Rudnitski, Anna; Sumpton, David; Ryan, Kevin M.; Cardaci, Simone published the artcile< D-mannose suppresses macrophage IL-1β production>, Formula: C6H12O6, the main research area is mannose macrophage IL1beta production.
D-mannose is a monosaccharide approx. a hundred times less abundant than glucose in human blood. Previous studies demonstrated that supraphysiol. levels of D-mannose inhibit tumor growth and stimulate regulatory T cell differentiation. It is not known whether D-mannose metabolism affects the function of non-proliferative cells, such as inflammatory macrophages. Here, we show that D-mannose suppresses LPS-induced macrophage activation by impairing IL-1β production In vivo, mannose administration improves survival in a mouse model of LPS-induced endotoxemia as well as decreases progression in a mouse model of DSS-induced colitis. Phosphomannose isomerase controls response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising intracellular mannose-6-phosphate levels. Such alterations result in the suppression of succinate-mediated HIF-1α activation, imposing a consequent reduction of LPS-induced Il1b expression. Disclosing an unrecognized metabolic hijack of macrophage activation, our study points towards safe D-mannose utilization as an effective intervention against inflammatory conditions.
Nature Communications published new progress about Animal gene, IL1B Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 3458-28-4 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Formula: C6H12O6.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts