《Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction》 was written by Slesarchuk, Nikita A.; Khvatov, Evgeny V.; Chistov, Alexey A.; Proskurin, Gleb V.; Nikitin, Timofei D.; Lazarevich, Anastasiya I.; Ulanovskaya, Angelina A.; Ulashchik, Egor A.; Orlov, Alexey A.; Jegorov, Artjom V.; Ustinov, Alexey V.; Tyurin, Anton P.; Shmanai, Vadim V.; Ishmukhametov, Aydar A.; Korshun, Vladimir A.; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Aralov, Andrey V.. HPLC of Formula: 13325-10-5 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:
Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5
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