Singh, Nidhi; Pandey, Jaya published their research in Current Research in Green and Sustainable Chemistry in 2021. The article was titled 《DABCO catalyzed, green and efficient, one-pot multicomponent synthesis of 5-aminopyrazole-4-carbonitrile》.Name: 3-Hydroxybenzaldehyde The article contains the following contents:
This work describes an unaccustomed DABCO catalyzed synthetic approach for the synthesis of 5-Aminopyrazole-4-carbonitriles I [R1 = H, 3-OH, 4-OH, 4-Br, 4-Cl, 4-OMe; R2 = H, 3,5-(NO2)2]. A series of substituted derivatives of 5-Aminopyrazole-4-carbonitrile I was synthesized deploying this facile and efficient catalyst in green aqueous media. The reaction involves condensation of malononitrile, benzaldehydes R1C6H4CHO and phenylhydrazines such as phenylhydrazine and 3,5-dinitrophenylhydrazine, generating one-pot pyrazole products. The mechanistic chem. of synthesis encompasses Knoevenagel condensation followed by amination and superseded by intra-mol. cyclization. The synthetic route is a lucid and effective route involving green solvent and less hazardous reaction conditions. Besides this, min. reaction period, easy work-up and elimination of byproducts during synthesis, make this reaction a model reaction for pyrazole synthesis. In the experiment, the researchers used many compounds, for example, 3-Hydroxybenzaldehyde(cas: 100-83-4Name: 3-Hydroxybenzaldehyde)
3-Hydroxybenzaldehyde(cas: 100-83-4) can be used as a reactant along with ethyl acetoacetate and thiourea in the synthesis of corresponding dihydropyrimidine-2-thione (monastrol), using Yb(OTf)3 as a catalyst by Biginelli cyclocondensation reaction.Name: 3-Hydroxybenzaldehyde
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