In 2019,Angewandte Chemie, International Edition included an article by Silva, Siguara B. L.; Oberhaensli, Francois; Tribalat, Marie-Aude; Genta-Jouve, Gregory; Teyssie, Jean-Louis; Dechraoui-Bottein, Marie-Yasmine; Gallard, Jean-Francois; Evanno, Laurent; Poupon, Erwan; Thomas, Olivier P.. Product Details of 13325-10-5. The article was titled 《Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges》. The information in the text is summarized as follows:
Among the outstanding chem. diversity found in marine sponges, cyclic guanidine alkaloids, present in species of the family Crambeidae, are particularly attractive, not only because of their unique chem. features, but also due to a broad range of biol. activities. Despite a growing interest in these natural products as therapeutic agents, their metabolic pathway has not been exptl. investigated. Ex situ feeding experiments using radiolabeled precursors performed on the Mediterranean sponge Crambe crambe suggest arginine and fatty acids as precursors in the metabolic pathway of crambescins. A subsequent bio-inspired approach supported the change of paradigm in the metabolic pathway of cyclic guanidine alkaloids. A large part of the chem. diversity of this family would therefore originate from a tethered Biginelli-like reaction between C-2/C-3 activated fatty acids and a central guanidinylated pyrrolinium. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5)
4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5
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