Siddiqui, Bina S.; Adil, Qayyum; Begum, Sabira; Siddiqui, Salimuzzaman published an article in Pakistan Journal of Pharmaceutical Sciences. The title of the article was 《Synthesis of alkyl catechols and evaluation of their antibacterial and cytotoxic activity》.Safety of 4-Butylbenzene-1,2-diol The author mentioned the following in the article:
A series of potential biol. active mono-, di- and tetra- alkyl catechols were prepared through Friedel- Crafts alkylation of catechol, and evaluated for their antibacterial and cytotoxic activity. The mono-substituted alkyl derivatives showed maximum antibacterial activity in vitro which increased with the increasing length of the alkyl chains. Primary screening results indicated that all the monoalkyl derivatives except 4- (2-octyl) catechol inhibited the growth of Bordetella bronchoseptica and maximum zones of inhibition were observed in case of monohexyl catechols (both n- and 2-hexyl) and monobenzyl derivative In case of Gram-neg. organisms growth of Klebsiella pneumoniae and Acinetobacter calcoaceticus was inhibited by several derivatives Mono-3-octyl-, monononyl- and monobenzyl catechols markedly inhibited the growth of Kl. pneumoniae. Mono-2-heptyl catechol inhibited the growth of six Gram-neg. bacteria. Min. inhibitory concentration of six most active compounds of the series was determined against Gram-pos. and Gram-neg. organisms; it ranged from > 100 μg/mL to 10μg/mL. The antibacterial activity of catechol was not significant. Cytotoxicity test done by brine shrimp assays showed that the order of cytotoxicity decreases in going from mono- to tetra- alkyl catechols, and among the mono- alkyl products, a decrease in order of cytotoxicity was noted in going from mono-Me catechol (LD50 = 59) to monopentyl catechol (LD50 = 173) after which the order of cytotoxicity gradually increased up to the largest alkyl substituent tested i.e. monononyl catechol (LD50 = 114). Me and Et catechol, which were almost inactive in respect of their antibacterial activity possessed pronounced cytotoxicity as compared to higher homologs. Catechol itself did not show significant cytotoxicity (LD50 = 393.27). The results came from multiple reactions, including the reaction of 4-Butylbenzene-1,2-diol(cas: 2525-05-5Safety of 4-Butylbenzene-1,2-diol)
4-Butylbenzene-1,2-diol(cas: 2525-05-5) belongs to organoboron compounds. Organoboron compounds are versatile intermediates and as such are some of the most important classes of reagents in modern organic chemistry. Organoboron compounds are less toxic than organostannane reagents, and unlike alkynylzinc and magnesium, many organoboron compounds possess remarkable oxidative and thermal stabilities. Safety of 4-Butylbenzene-1,2-diol
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