Sashidhara, Koneni V.; Modukuri, Ram K.; Singh, Seema; Bhaskara Rao, K.; Aruna Teja, G.; Gupta, Sampa; Shukla, Shubha published an article on January 15 ,2015. The article was titled 《Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Related Products of 153759-59-2 The information in the text is summarized as follows:
A new series of coumarin based aminopyran derivatives I [ R1 = Me, iso-Pr, sec-Bu, tert-Bu; R2 = H, OMe; R3 = OMe; R4 = H, OMe; R5 = H, Me] were designed, synthesized and evaluated for their preclin. antidepressant effect on Swiss albino mice. Among the series, compounds I [ R1 = iso-Pr, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = iso-Pr, R2 = R4 = = R5 = H, R3 = OMe; R1 = iso-Pr, R2 = R5 = H, R3 = R4= OMe; R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me; R1 = sec-Bu, R2 = R4 = H, R3 = OMe, R5 = Me; R1 = sec-Bu, R2 = H, R3 = R4= OMe, R5 = Me] exhibited significant activity profile in forced swimming test (FST). Compound I [R1 = iso-Pr, R2 = H, R3 = R4= OMe, R5 = Me] was most efficacious, which at a very low dose of 0.5 mg/kg reduced the time of immobility by 86.5% as compared to the standard drug fluoxetine (FXT) which reduced the immobility time by 69.8% at the dose of 20 mg/kg, i.p. In addition, all active compounds were screened in dose dependent manner (at doses of 0.25, 0.5, 1 mg/kg i.p.) in FST and tail suspension test (TST). Interestingly, all active compounds did not caused any significant alteration of locomotor activity in mice as compared to control, indicating that the hybrids did not produce any motor impairment effects. The results indicate that coumarin-aminopyran derivatives may have potential therapeutic value for the management of mental depression. After reading the article, we found that the author used 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Related Products of 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).Related Products of 153759-59-2
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