Recommanded Product: 153759-59-2On October 15, 2014 ,《Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Sashidhara, Koneni V.; Rao, K. Bhaskara; Singh, Seema; Modukuri, Ram K.; Aruna Teja, G.; Chandasana, Hardik; Shukla, Shubha; Bhatta, Rabi S.. The article contains the following contents:
A series of amine substituted 3-phenylcoumarin derivatives was designed and synthesized as potential antidepressant agents. In preliminary screening, all compounds were evaluated in forced swimming test (FST), a model to screen antidepressant activity in rodents. Among the series, compounds I and II potentially decreased the immobility time by 73.4% and 79.7% at a low dose of 0.5 mg/kg as compared to standard drug fluoxetine (FXT) which reduced the immobility time by 74% at a dose of 20 mg/kg, i.p. Addnl., these active compounds also exhibited significant efficacy in tail suspension test (TST) (another model to screen antidepressant compounds). Interestingly, rotarod and locomotor activity tests confirmed that these two compounds do not have any motor impairment effect and neurotoxicity in mice. Our studies demonstrate that the new 3-phenylcoumarin derivatives may serve as a promising antidepressant lead and hence pave the way for further investigation. The experimental process involved the reaction of 5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2Recommanded Product: 153759-59-2)
5-(tert-Butyl)-4-hydroxyisophthalaldehyde(cas: 153759-59-2) belongs to phenols.Recommanded Product: 153759-59-2Deprotonation of a phenol forms a corresponding negative phenolate ion or phenoxide ion, and the corresponding salts are called phenolates or phenoxides (aryloxides according to the IUPAC Gold Book).
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