Qiu, Lin; Xiao, Chao-Jiang; Shen, Yi; Xu, Wei; Liu, Xiao-Bo; Dong, Xiang; Jiang, Bei published the artcile< Bioactive hydroxypropionylated glucose derivatives from Astragalus bhotanensis>, Reference of 492-62-6, the main research area is hydroxypropionylated glucose derivative isolation Astragalus bhotanensis pharmacodynamics; Astragalus bhotanensis; Leguminosae; analgesic; antioxidant; cytotoxicity; hydroxypropionylated glucose derivatives.
Four previously undescribed hydroxypropionylated D-glucose derivatives, astrabhotins A-D, along with ten known compounds α-D-glucose, β-D-glucose, quebrachitol, 3-hydroxypropionic acid, oleic acid, isoliquiritigenin, liquiritigenin, odoratin, 7β-hydroxysitosterol and daucosterol, were isolated from the roots of Astragalus bhotanensis. Their structures were elucidated based on the analyses of extensive spectroscopic data and physicochem. properties. Astrabhotin A reduced the writhing response remarkably with 52.5% inhibition by acetic acid induced writhing test. The analgesic effect of was stronger than the standard drug aspirin. In addition, compounds and showed significant antioxidant activities with IC50 values of 9.9 ± 0.2 and 7.9 ± 0.4 μg/mL, and exhibited weak or moderate cytotoxicity against HepG2 cells with IC50 values of 106.6 ± 2.7 and 42.0 ± 0.9 μg/mL, resp.
Natural Product Research published new progress about Analgesics. 492-62-6 belongs to class alcohols-buliding-blocks, and the molecular formula is C6H12O6, Reference of 492-62-6.
Referemce:
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Alcohols – Chemistry LibreTexts