《Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenyl-methanols using K2CO3/n-Bu4PBr in water》 was written by Pillaiyar, Thanigaimalai; Sedaghati, Masoud; Schnakenburg, Gregor. Product Details of 7748-36-9This research focused ontrifluoromethyl indolyl phenyl methanol preparation regioselective; indole fluoromethyl ketone Friedel Crafts alkylation; C3-funtionalization of indole; C–C-bond formation; Friedel–Crafts reaction; diindolylmethane; indole; indole-3-carbinol; large-scale synthesis; recyclability. The article conveys some information:
A new, mild and efficient protocol is provided for the synthesis of trifluoromethyl(indolyl)phenylmethanols e.g., I by the reaction of indoles e.g., 5-methoxyindole with a variety of aromatic fluoromethyl ketones RC(O)C(R1)F2 (R = Ph, Bn, thiophen-2-yl, etc.; R1 = H, F, Cl, CF3, etc.) in the presence of K2CO3 (15 mol) and n-Bu4PBr (15 mol) in water. The desired products were obtained in good to excellent yields without requiring a column chromatog. purification The reusability of the catalytic system and large-scale synthesis of indolyl(phenyl)methanols e.g., I, which would further transform into biol. active indole-derived compounds, are further advantages of this protocol. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)
Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9
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