Pandey, Bedraj; Xu, Shi; Ding, Keying published the artcile< Switchable β-alkylation of Secondary Alcohols with Primary Alcohols by a Well-Defined Cobalt Catalyst>, Electric Literature of 403-41-8, the main research area is alkylation primary secondary alc preparation cobalt triphosphine pyridine catalyst; switchable ketone secondary alc preparation alkylation benzenemethanol cobalt catalyst.
β-Alkylation of secondary alcs. R1CH(OH)Me with primary alcs. R2CH2OH catalyzed by cobalt(I) triphosphine-pyridine complex in the presence of KOtBu selectively generate either alcs. R1CH(OH)CH2CH2R2 or ketones R1COCH2CH2R2 in dependence of catalyst and base loadings and hydrogen presence or removal. Remarkably, a low catalyst loading of 0.7 mol% can be employed for the reaction. More significantly, this study represents the first Co-catalyzed switchable alc./ketone synthesis by simply manipulating the reaction parameters. In addition, the transformation is environmentally friendly, with water as the only byproduct.
Organometallics published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts