《Phoenix dactylifera fruit extract ameliorates altered biochemical parameters in streptozotocin-induced diabetes mellitus albino rats》 was written by Ogo, A. O.; Abah, S. F.; Inalegwu, B.; Eru, U. E.. Safety of 2-Aminopropane-1,3-diol And the article was included in International Journal of Current Pharmaceutical Research in 2020. The article conveys some information:
Objective: Consistent projections have indicated a steady increase in the global burden of diabetes mellitus. Given the increased cost in conventional management of the condition in addition to reported side effects and cost of orthodox management, attention is shifting to the use of alternative methods such as plants materials with dual benefits as food and medicine. Thus, this study was designed to investigate the effect of date palm fruit on some biochem. parameters in streptozotocin-induced wistar rats. Methods: Animals were divided into 5 groups of 6 rats each (I as normal control, II as diabetic control and 3-5 as extract-treated groups) maintained for 14 d. At the end of the treatment, the animals were fasted overnight, then sacrificed and blood samples collected for anal. of biochem. parameters (including blood glucose, blood lipids and enzymes). Results: The results show that treatment of diabetic animals with extract of date palm fruit show a significant (P<0.05) reduction in glucose levels in groups II-V compared to group I. Similar pos. effects were observed in the levels of lipids and enzymes in treated groups compared to diabetic control group II. A GC-MS anal. of the fraction of the fruit extract revealed some bioactive compounds that may be responsible for the effects exhibited in the study. Conclusion: These findings which demonstrate the ameliorative effect on hyperglycemia and hyperlipidemia, further support the use of date palm fruit as a nutraceutical agent. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)
2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 2-Aminopropane-1,3-diol
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