《Stereoselective Tandem Bis-Electrophile Couplings of Diborylmethane》 was written by Murray, Stephanie A.; Liang, Michael Z.; Meek, Simon J.. Product Details of 78782-17-9This research focused onthree component coupling diborylmethane epoxide allyl bromide preparation hydroxyboronate; diol hydroxyboronate chiral preparation stereoselective borylation ring opening epoxide. The article conveys some information:
A copper-catalyzed three-component linchpin coupling method for the stereoselective union of readily available epoxides R1R2C(O)CHR3 with diborylmethyl lithium (pinB)2CHLi and allyl electrophiles is disclosed; the reaction afforded borylated alc. derivatives R1R2C(OX)CH2CHBpinCH2CH:CH2 (X = TBSO, H) or the corresponding 1,3-diols R1R2C(OH)CH2CH(OH)CH2CH:CH2 after oxidation Transformations employ [B(pin)]2-methane as a conjunctive reagent, resulting in the formation of two C-C bonds at a single carbon center bearing a C(sp3) organoboron functional group. Products are obtained in 42-99% yield, and up to >20:1 dr. The utility of the approach is highlighted by stereospecific transformations entailing allylation, tandem cross coupling, and application to the synthesis 1,3-polyol motifs. In the experiment, the researchers used Bis[(pinacolato)boryl]methane(cas: 78782-17-9Product Details of 78782-17-9)
Bis[(pinacolato)boryl]methane(cas: 78782-17-9) belongs to organoboron compounds.Product Details of 78782-17-9 Organoboron compounds have been a cornerstone of synthetic transformations for decades. Areas such as boron-containing catalysts, metalate chemistry, photoredox methods, and boryl anions have brought significant new developments in understanding and provided new reactivity upon.
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