Ma, Shuang-Jiang; Yu, Jie; Yan, Da-Wei; Wang, Da-Cheng; Gao, Jin-Ming; Zhang, Qiang published the artcile< Meroterpene-like compounds derived from β-caryophyllene as potent α-glucosidase inhibitors>, Formula: C8H6O5, the main research area is meroterpene derivative preparation beta caryophyllene glucosidase inhibitor antidiabetic agent.
Meroterpenoids isolated from guava (Psidium guajava) and Rhodomyrtus tomentosa possess special skeletons which incorporate terpenoids with phloroglucinol derivatives Most of these meroterpenoids showed high cytotoxicity against cancer cell lines. However, their chem. diversity is very limited. Here, we employed a biomimetic hetero-cycloaddition starting from ortho-quinone methides and an abundant natural product, β-caryophyllene, to generate meroterpene-like compounds Considering that the source plant has hyperglycemic functions, α-glucosidase was selected as a target for bioassay. Nine compounds were screened out for promising activities (IC50 < 15 μM), which were better than the pos. controls, genistein and acarbose. The best inhibitor 12 (IC50 = 2.73 μM) possessed 2 caryophyllene moieties. They represented a new type of skeleton possessing activities against α-glucosidase. The kinetic study exhibited that these inhibitors belong to a non-competitive type. All of these inhibitors may provide an opportunity to develop a new class of antidiabetic agents. Organic & Biomolecular Chemistry published new progress about Antidiabetic agents. 4396-13-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H6O5, Formula: C8H6O5.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts