Liu, Can; Shen, Ni; Shang, Rui published the artcile< Photocatalytic defluoroalkylation and hydrodefluorination of trifluoromethyls using o-phosphinophenolate>, Application In Synthesis of 627-27-0, the main research area is alkene aryl trifluoroacetamide phosphinophenolate catalyst defluoroalkylation hydrodefluorination; difluoro aryl alkyl amide preparation; trifluoroacetate alkene phosphinophenolate catalyst defluoroalkylation; alkyl difluoro ester preparation; alkenol trifluoromethyl arene phosphinophenolate catalyst defluoroalkylation; arenyl difluoroalkanol preparation.
Under visible light irradiation, o-phosphinophenolate functions as an easily accessible photoredox catalyst to activate trifluoromethyl groups in trifluoroacetamides, trifluoroacetates and trifluoromethyl (hetero)arenes to deliver corresponding difluoromethyl radicals. It works in relay with a thiol hydrogen atom transfer (HAT) catalyst to enable selective defluoroalkylation and hydrodefluorination. The reaction allowed for the facile synthesis of a broad scope of difluoromethylene-incorporated carbonyl and (hetero)aromatic compounds, which are valuable fluorinated intermediates of interest in the pharmaceutical industry. The ortho-diphenylphosphino substituent, which is believed to facilitate photoinduced electron transfer, plays an essential role in the redox reactivity of phenolate. In addition to trifluoromethyl groups, pentafluoroethyl groups could also be selectively defluoroalkylated.
Nature Communications published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts