Liu, Can; Li, Kang; Shang, Rui published the artcile< Arenethiolate as a Dual Function Catalyst for Photocatalytic Defluoroalkylation and Hydrodefluorination of Trifluoromethyls>, Recommanded Product: But-3-en-1-ol, the main research area is difluoroarene preparation; trifluoroarene thiol catalyst photochem defluoroalkylation; difluoroamide preparation; trifluoroacetamide thiol catalyst photochem defluoroalkylation; difluoroacetate preparation; trifluoroacetate thiol catalyst photochem defluoroalkylation.
An arene thiolate with an appropriate substituent was photoactivated under visible light to function as both a strongly reducing electron-donating redox catalyst and a HAT catalyst to enable catalytic C-F activation of trifluoromethyl substrates for selective hydrodefluorination and coupling with various alkenes in the presence of formate salts. These reactions demonstrated the promising utility of arenethiolates as dual function photocatalysts. The synthetic utility of this method was demonstrated by the broad scope of amenable trifluoromethyl substrates, including trifluoromethylated (hetero)arenes, trifluoroacetates, and trifluoroacetamides, which exhibited high levels of chemoselectivity. The reaction efficacy allowed site-selective late-stage functionalization of multitrifluoromethylated bioactive compounds and pharmaceuticals.
ACS Catalysis published new progress about Acetamides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (trifluoro). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.
Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts