Li, Huige; Xia, Ning; Hasselwander, Solveig; Daiber, Andreas published the artcile< Resveratrol and vascular function>, Quality Control of 501-36-0, the main research area is review resveratrol blood pressure vascular function; cardiovascular disease; endothelial nitic oxide synthase; endothelium; resveratrol; sirtuin 1; vascular function.
A review. Resveratrol increases the production of nitric oxide (NO) in endothelial cells by upregulating the expression of endothelial NO synthase (eNOS), stimulating eNOS enzymic activity, and preventing eNOS uncoupling. At the same time, resveratrol inhibits the synthesis of endothelin-1 and reduces oxidative stress in both endothelial cells and smooth muscle cells. Pathol. stimuli-induced smooth muscle cell proliferation, vascular remodeling, and arterial stiffness can be ameliorated by resveratrol as well. In addition, resveratrol also modulates immune cell function, inhibition of immune cell infiltration into the vascular wall, and improves the function of perivascular adipose tissue. All these mechanisms contribute to the protective effects of resveratrol on vascular function and blood pressure in vivo. Sirtuin 1, AMP-activated protein kinase, and estrogen receptors represent the major mols. mediating the vascular effects of resveratrol.
International Journal of Molecular Sciences published new progress about Adipose tissue. 501-36-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C14H12O3, Quality Control of 501-36-0.
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